Hyperemesis gravidarum is a rare condition that occur about one in 500 Pregnancies. Weight loses ketoacidosis and serum electrolytes imbalance may occur as the result of hyperemesis. Meanwhile the cause is unknown, some factors such as high HCG level transient hypothyroidism; psychological instability are said to be responsible. Furthermore, the researchers have found some relations between hyperemesis and helicobacter pylori infection. Various methods are used to treat hyperemesis such as acupuncture; hypnosis and gingers root.

Background: Hyperemesis Gravidarum is the pernicious vomiting during pregnancy that causes various complications. This present was investigated to relationship between Helicobacter Pylori and Hyperemesis Gravidarum.Methods and Materials: 80 women with 7-16 gestational age, participated in this casecontrol study. It was done in Obstetric Clinical of Shabihkhani Hospital in Kashan from April to July 2008.The case group had Hyperemesis Gravidarum but the control group did not. The criteria for Hyperemesis Gravidarum were pernicious vomiting (more than 3 times a day) and the presence of one pluse ketonuria. Serum titre of anti Helicobacter pylori IgG with standard ELAZA kit in each group then compared. Chi square test was applied for data analysis and significancy was P-Value less than 0.05.Results: The mean of age was 25.4±4.5 in case and 22.4±4.6 in control group. There were no statistically significant differences in age, gestational age, gravity and parity between two groups. The frequency of Helicobacter Pylori was 75% in case and 35% in control group. Difference was significant (p=0.001).Conclusion: In this study, significant relationship between Hyperemesis Gravidarum and Helicobacter Pylori was seen. Regarding to Helicobacter Pylori causes peptic ulcer and hyperemesis imitates some Peptic ulcer symptoms, more studies should be carried out to determine this relationship.

Background: Hyperemesis gravidarum is one of the pregnancy complications which leads to decreased efficiency of pregnant women. Objective: To examine a hypothesis indicative of the presence of an association between hyperemesis gravidarum (HG) and Helicobacter pylori (HP) infection. Methods: This work was a case control study carried out on 35 pregnant women with HG (study group) and 35 asymptomatic pregnant women (control group) admitted to Kosar hospital, Qazvin, Iran in a six-month period between 2003-2004. Serum specific IgG for HP was assayed on the sera of both studies a control groups after formal agreement was made. Data were analysed statistically using Chi-square and student t tests. Findings: Serologically positive HP infection was detected in 23 out of 35 patients with HG (%65.7) whereas in control group, only 7 out of 35 asymptomatic gravidas (%20) were found to have positive antibody titers against HP. The ratio of HP positivity in pregnant women with HG was significantly higher than asymtomatic group (P<0.004). The mean index percentages of IgG titers in study and control groups were 27± 30  and 10 ±13, respectively. Conclusion: HP infection seemed to be significantly associated with HG in pregnant population with hyperemesis gravidarum investigated in our study.  

Background: There are also reports from other parts of the world indicating the presence of significant association of H. pylori infection and hyperemesis gravidarum, a bothersome condition that affects pregnant women. Objective: To test the hypothesis that whether H. pylori infection is associated with hyperemesis gravidarum among Iranian H.P carriers. Methods: From November 1999 to February 2001, we enrolled 54 pregnant women with hyperemesis gravidarum and 53 asymptomatic pregnant women (control group) in a prospective study. Using a specific serum IgG against H. pylori, the seroprevalence of H. pylori infection was determined in both study and control groups. Results: Serologically positive H. pylori infection was detected in 44 (82%) out of 54 patients with hyperemesis gravidarum and 29 (55%) out of 53 asymptomatic pregnant women. The prevalence was significantly (p<0.01) higher in those with hyperemesis gravidarum than those in the control group. The mean±SD of the IgG titer in the study group (69.7±77.5) was significantly (p<0.01) more than that of the control group (34.5±47.8). Conclusion: H. pylori infection may cause hyperemesis gravidarum.

Severe nausea and vomiting associated with weight loss, ketonemia, and electrolyte imbalance in pregnancy is called hyperemesis gravidarum (HG). Its cause is unknown but there are some hypotheses like hormonal mechanisms, psychological and emotional factors and Helicobacter pylori infection. The aim of this study was to find an association between (HG) and H. pylori infection. For this purpose in a prospective study from Aug. 2001 to Feb. 2002, the serum antibodies against H. pylori in 39 patients with HG was compared with IgG titers of 55 asymptomatic pregnant women at the same gestational age as controls. Venous blood was taken after the patients had given their written consent. Specific serum antibodies (immunoglobulin IgG) directed against H. pylori was measured by fluorescent enzyme-immunoassay. IgG titers less than 15 was considered negative, IgG titers more than 20 were regarded positive and IgG titers between 15-20 were considered as suspicious and required repeating the test after 2-4 weeks. Chi square, Mann Whitney and Student t test were used for statistical analysis of the data. Positive serum IgG concentrations were found in 26 of the 39 hyperemesis patients (66.7%) compared with 23 of 55 controls (41.8%). The difference was statistically significant(P<0.015). The mean IgG titers in hyperemesis group were 25 compared to 10.5 in control group(P<0.05). It seems that H. pylori infection is significantly associated with HG.

Background: despite high prevalence rate of nausea vomiting and mead for treatment in severe cases which leads to electrolyte imbalances and weight loss, due to lack of knowledge about its cause, an elear-cut treatment for it, is still unavailable. In this study we compared the effect of prednisolone to that of pyridoxine on the treatment of severe cases of vomiting during the first half of pregnancy. Methods and Materials: In a double blind clinical trial study (2002-2003) 120 women with a normal intra uterine pregnancy and less than 22 weeks of gestational age with hyper emesis gravidarum were admitted to Zahedan Qhods hospital for appropriate treatment. Patients randomly divided in two groups of 60; patients, received prednisolone 5mg /TDS (case group) and the other 60 patients, received pyridoxine / 20mg/ TDS (control group). 3 days later, serum electrolytes, severity of vomiting, beginning of diet, and response to treatment were studied. All patients were followed every week, up to 22 weeks of gestational age. Results: There was no significant difference between the two groups with respect to maternal age, gestational age, and gravidity, and weight loss, number of previous admissions recent pregnancy. There was significant difference between the two groups in electrolyte disorders, start of feeding after 1-2 days from initiated treatment, recurrent admission 2 weeks after discharge and response to treatment (P≤ 0.001).90% of the patients in prednisolone group and 61.7% of pyridoxine group responded positively to the treatment. 3 days after the commencement of the treatment, 18 people in prednisolone group and 5 in pyridoxine still had electrolyte imbalances. The proportion of vomiting and hypocalemi modification in prednisolone consumer were, respectively consumer 4.5 and 4.7 as much as pyriodoxine and the likeliyhood of the relapse of vomiting in pyridoxine consumer was 3.3 as much as prednisolone. Conclusions: A short course of a little prednisolone therapy was more effective than pyridoxine in treatment of hyper emesis gravidarum.